Hull City’s winless and goalless run extended to six matches as two goals in four second-half minutes earned Blackburn a comfortable victory.
Daniel Ayala’s bullet header from Joe Rothwell's corner and Chile international Ben Brereton Diaz’s fine curling finish consigned the Tigers to a fourth defeat of the season.
Richie Smallwood was handed the captain’s armband against his former club as Grant McCann made two changes from the goalless draw with Swansea City.
Matt Smith also came in as George Moncur dropped to the bench, with Tom Huddlestone rested and Andy Cannon returning to the matchday 18.
The Tigers, who arrived at Ewood Park on the back of two creditable scoreless draws against AFC Bournemouth and the Swans, started positively in East Lancashire.
Lewie Coyle’s sumptuous crossfield pass, executed first time on the half-volley, perfectly picked out the run of Keane Lewis-Potter, who checked inside Ryan Nyambe before blazing high over the bar.
Leighton Clarkson volleyed well wide from a partially-cleared corner as Rovers responded, with Tyrhys Dolan showing quick feet before curling a delightful right-footed effort inches wide.
City controlled the rest of the half; Matt Smith span on a sixpence before seeing a drive blocked by Ayala and Lewis-Potter jinked away from Dolan before skying from 25 yards.
The visitors continued to ask questions, with Josh Magennis’ fizzing shot from the edge of the box beaten away by Rovers keeper Thomas Kaminski.
Dolan reminded the Tigers’ defence of his talents six minutes before the break with another jinking run and bending shot, reminiscent of his earlier one, which Matt Ingram swatted away.
Mallik Wilks’ left-footed strike was held by Kaminski, who took two attempts to gather Lewis-Potter’s shot from the corner of the box early in the second half.
The Tigers thought their wait for a goal was over when a stretching Magennis diverted Callum Elder’s precise centre past a wrong-footed Kaminski – but the linesman's flag was raised for offside.
Blackburn boss Tony Mowbray had seen enough and made an inspired double change on 54 minutes, bringing on Reda Khadra and Dan Butterworth.
The substitutes immediately got into the thick of the action as Khadra shot straight at Ingram and a Butterworth effort was blocked by Coyle.
Butterworth’s long-range strike was then pushed back out unconvincingly by Ingram, with an off-balance Dolan unable to gobble up the rebound, as the pendulum swung Rovers' way.
And the pressure told on 61 minutes as Ayala rose above Jacob Greaves to power a header beyond a helpless Ingram from Rothwell’s pinpoint corner.
With Rovers' tails up, Brereton Diaz’s near-post strike was palmed away by Ingram after a strong run by Butterworth and Lewis Travis’ sweet outside-of-the-boot half-volley whistled narrowly wide.
The Tigers were unable to live with the Blackburn bombardment and conceded a sublime second on 65 minutes, Brereton Diaz picking out the bottom corner with a bending drive from 16 yards.
The 10-minute blitz had taken the game away from the visitors, who introduced Moncur and Ryan Longman from the bench, followed not long after by Tyler Smith.
Butterworth shot into the side-netting and Brereton Diaz dragged wide, while a well-hit Moncur effort was parried by Kaminski before the midfielder curled another attempt over.
Moncur was looking the most likely to drag Hull City back into the contest, steering wide from outside the box via a deflection and curling another long-range shot wide.
The Tigers never stopped trying and continued to search for that elusive goal but the efforts proved to no avail as Rovers saw out the closing stages with little concern.
Blackburn Rovers: Thomas Kaminski; Ryan Nyambe, Darragh Lenihan ©, Daniel Ayala, Harry Pickering; Lewis Travis, Joe Rothwell, Leighton Clarkson (Dan Butterworth 54’), John Buckley (Reda Khadra 54’), Ben Brereton Diaz, Tyrhys Dolan (Jacob Davenport 89’).
Subs not used: Aynsley Pears, Hayden Carter, Connor McBride, Tyler Magloire.
Hull City: Matt Ingram; Lewie Coyle, Di’Shon Bernard, Jacob Greaves, Callum Elder; Richie Smallwood ©, Matt Smith (George Moncur 67’), Greg Docherty; Mallik Wilks (Tyler Smith 77’), Josh Magennis (Ryan Longman 68’), Keane Lewis-Potter.
Subs not used: Nathan Baxter, Josh Emmanuel, Andy Cannon, Sean McLoughlin.
Attendance: 9,140 (463 Hull City supporters).